"Although drugs currently used to treat HIV can suppress replication, they cannot remove the proviral DNA from the infected cell's genome.
"This work uses CRISPR/Cas9 genome editing technology to excise proviral DNA from infected human cells embedded in the tissues of experimental animals.
Dr Wenhui Hu, of Temple University, told the the new study built on earlier research but was “more comprehensive”.
In one of the most highly publicised statements, in October 2003, the President of the Vatican's Pontifical Council for the Family, Cardinal Alfonso Lopez Trujillo, said: "The AIDS virus is roughly 450 times smaller than the spermatozoon.
The spermatozoon can easily pass through the 'net' that is formed by the condom.
They admitted there were still some practical problems to be overcome, but suggested their work was a “significant step” towards carrying out clinical trials of the technique on humans.
, the scientists described how some of the mice had been “humanised” after being given some human immune cells.
“They claim that by combining a number of the tools necessary for gene editing in a single delivery vector they have increased the efficiency of gene targeting,” he added.
“This undoubtedly shows promise but some big questions remain – how much of the latent reservoir do you need to target and will it work in humans?Moral questions about condom use are not within the remit of this resource, but questions of fact are, and condoms’ ability to stop HIV is periodically questioned by people opposed to their use on religious or moral grounds.Therefore questions of condom efficacy have to be addressed and misapprehensions corrected.Apparent breakthroughs in animal models often encounter problems later in the process of developing a treatment for humans.Nonetheless, the researchers, from Temple University and Pittsburgh University in the US, wrote in the journal that this type of genome editing “provides a promising cure for HIV-1/Aids”.“We also show that the strategy is effective in two additional mouse models, one representing acute infection in mouse cells and the other representing chronic, or latent, infection in human cells.” Professor Jonathan Ball, an expert in molecular virology at Nottingham University, told that gene editing was seen as a potential way to effectively cure people of the disease.